• Any abnormality causing a loss of function

  2019-05-06

  

  Any abnormality causing a loss-of-function in the IKs macromolecular complex may lead to adrenergic-induced imbalance in ventricular repolarization currents and consequent QTc prolongation, which is identified based on the defective response of IKs to PKA stimuli due to mutations in KCNQ1 (-G269S, -

• Is this perhaps a manifestation of the

  2019-05-06

  

  Is this perhaps a manifestation of the unequal distribution of growth, reflecting a pattern whereby income increases over the past two decades have benefited only the better-off? The evidence suggests that this is unlikely: across countries, Vollmer and colleagues report similar associations between

• All patients with rickettsial infections reported by

  2019-05-06

  

  All patients with rickettsial infections reported by Dittrich and colleagues presented with fever at admission, and few patients presented with typical eschars of inoculation (only 3·6% of patients with murine typhus and 6·7% with scrub typhus). This finding might be a result of poor awareness about

• En las reflexiones sobre la

  2019-05-06

  

  En las reflexiones sobre la “Isla del Encanto” de María Teresa Cortés en su aportación titulada “La configuración de la nación en la narrativa histórica puertorriqueña y el sistema de prácticas ecológicas, siglo ” retoma la labor informativa sobre Puerto Rico, hecha por el funcionario español de ori

• En este contexto a juicio de Svampa cohabitan

  2019-05-05

  

  En este contexto, custom synthesis juicio de Svampa, cohabitan en el campo contestatario latinoamericano cuatro matrices político-ideológicas que dan cuenta de diferentes perspectivas en relación con la manera de pensar la política y el poder, así como los procesos de cambio social. Estas matrices s

• Con Lemebel y Perlongher y la

  2019-05-05

  

  Con Lemebel y Perlongher, y la resonancia que en ellos tienen Gilíes Deleuze y Félix Guattari, puede percibirse un gesto de queeridad sudamericano, un “infinito devenir minoritario, nómade, siempre en movimiento, en el que podemos leer la emergencia de una mirada que se acerca propyl lo queer de man

• The patient was consented to treatment on

  2019-05-05

  

  The patient was consented to treatment on clinical trial NCT02527447 and received treatment with salvage chemotherapy of mitoxantrone 12mg/m2/day IV on days 1–3, etoposide 200mg/m2/day continuous IV infusion (CIV) on days 8–10, and cytarabine 500mg/m2/day CIV on days 1–3 and 8–10 (EMA). Infectious p

• In the days before Christmas adverse weather conditions and

  2019-05-05

  

  In the days before Christmas, 1952, adverse weather conditions and the burning of sulphurous coal led to the death of almost 12 000 people in London. Despite improvements in pollution prevention since the “Great Smog”, London continues to experience toxic air pollution linked to thousands of prematu

• In Alexandre de Figueiredo and

  2019-05-05

  

  In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when colorimetric assay coverage might

• It has been speculated that the geographical

  2019-05-05

  

  It has been speculated that the geographical variation among radiotherapy prescription is a function of the respective healthcare systems within each region. If physicians receive greater reimbursement for multiple fractions compared to a single fraction, they will likely have greater willingness to

• Pilsicainide might increase hERG proteins via facilitating

  2019-05-05

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• With this in mind we were

  2019-05-05

  

  With this in mind, we were dismayed that the 133rd session of the WHO Executive Board last year failed to reach consensus on the adoption of a provisional agenda on improving the health and wellbeing of LGBT people. Young people have shown an aptitude for co-operation in improving LGBT health where

• br Conclusion br Conflict of interest br Introduction Classi

  2019-05-04

  

  Conclusion Conflict of interest Introduction Classically, cancer has been described as a disease involving uncontrolled cell growth. Now, however, it is apparent that cancer growth and metastasis are not solely dependent on the tumor abk themselves, but involve pathologies in the surroundi

• br Adverse events Treatment reported toxicities were

  2019-05-04

  

  Adverse events Treatment reported toxicities were similar to those previously reported [23]. Discussion Several other studies have addressed the same issue using different bisphosphonates. The SABRE study randomised breast cancer patients taking anastrozole with a T-score of between −1 and −2

• br In their Comment on the use

  2019-05-04

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

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