• The patient was consented to treatment on

  2019-05-05

  

  The patient was consented to treatment on clinical trial NCT02527447 and received treatment with salvage chemotherapy of mitoxantrone 12mg/m2/day IV on days 1–3, etoposide 200mg/m2/day continuous IV infusion (CIV) on days 8–10, and cytarabine 500mg/m2/day CIV on days 1–3 and 8–10 (EMA). Infectious p

• In the days before Christmas adverse weather conditions and

  2019-05-05

  

  In the days before Christmas, 1952, adverse weather conditions and the burning of sulphurous coal led to the death of almost 12 000 people in London. Despite improvements in pollution prevention since the “Great Smog”, London continues to experience toxic air pollution linked to thousands of prematu

• In Alexandre de Figueiredo and

  2019-05-05

  

  In , Alexandre de Figueiredo and colleagues take a step in this direction with their time-series analysis of trends in vaccine coverage and a suite of socioeconomic and demographic factors across 190 countries over 30 years. The main aim was to gauge where and when colorimetric assay coverage might

• It has been speculated that the geographical

  2019-05-05

  

  It has been speculated that the geographical variation among radiotherapy prescription is a function of the respective healthcare systems within each region. If physicians receive greater reimbursement for multiple fractions compared to a single fraction, they will likely have greater willingness to

• Pilsicainide might increase hERG proteins via facilitating

  2019-05-05

  

  Pilsicainide might increase hERG proteins via facilitating the transcription of hERG from DNA to RNA or the translation of hERG RNA into hERG protein. Qualitative RT-PCR demonstrated the absence of an increase in hERG mRNA expression levels after pilsicainide treatment (Supplemental Fig. S2), indica

• With this in mind we were

  2019-05-05

  

  With this in mind, we were dismayed that the 133rd session of the WHO Executive Board last year failed to reach consensus on the adoption of a provisional agenda on improving the health and wellbeing of LGBT people. Young people have shown an aptitude for co-operation in improving LGBT health where

• br Conclusion br Conflict of interest br Introduction Classi

  2019-05-04

  

  Conclusion Conflict of interest Introduction Classically, cancer has been described as a disease involving uncontrolled cell growth. Now, however, it is apparent that cancer growth and metastasis are not solely dependent on the tumor abk themselves, but involve pathologies in the surroundi

• br Adverse events Treatment reported toxicities were

  2019-05-04

  

  Adverse events Treatment reported toxicities were similar to those previously reported [23]. Discussion Several other studies have addressed the same issue using different bisphosphonates. The SABRE study randomised breast cancer patients taking anastrozole with a T-score of between −1 and −2

• br In their Comment on the use

  2019-05-04

  

  In their Comment on the use of antenatal corticosteroids to reduce preterm infant deaths, Kishwar Azad and Anthony Costello advise “extreme caution” before scale-up in low-income settings. They emphasise maternal sepsis as a concern but cite only one trial in which dexamethasone resulted in a sign

• Undoubtedly hydroxyurea has a huge potential for

  2019-05-04

  

  Undoubtedly, hydroxyurea has a huge potential for improving the quality of lives of people affected by sickle-cell anaemia in settings where frequent and probably unsafe blood transfusions are the current standard of care. However, attention needs to be directed towards the potential adverse effects

• La Brev ssima relaci n de

  2019-05-04

  

  La Brevíssima relación de la destruyción de las Indias de fray Bartolomé de las Casas, fechada el 8 de diciembre de 1542, se publica en el año 1552 (“… fue rogado e importunado que destas postreras pusiesse algunas por brevedad por escrito”). Finalmente es condenada en 1660 por el Tribunal de la Inq

• Outra implica o envolvida com as

  2019-05-04

  

  Outra implicação envolvida com as os e que tem sido uma das principais bandeiras levantada por entidades contrárias é THZ1 manufacturer considerada terceirização da saúde pública. A terceirização foi assumida por alguns agentes envolvidos no processo, como o ex-secretário de saúde paulista e sanita

• Interpretation Patient centred medical education can improve

  2019-05-04

  

  Interpretation Patient-centred medical education can improve overall satisfaction and sustained disease-specific knowledge in patients in Uganda. Our results show that printed booklets are accepted by patients and feasible to implement in a LMIC outpatient setting. Funding Trishul Siddharthan recei

• URMC-099 Reframing non communicable diseases NCDs

  2019-05-04

  

  Reframing non-communicable diseases (NCDs) to “spur a sense of urgency” and “focus attention on effective system-wide interventions” makes sense. With almost three-quarters of NCD deaths now occurring in low-income and middle-income countries (LMICs), the increasing burden of NCDs already has severe

• Dyslipidemia is characterized by increased total cholesterol

  2019-05-04

  

  Dyslipidemia is characterized by increased total cholesterol, LDL-C, and triglyceride levels, and decreased HDL-C levels. However, the association of ApoA1 polymorphism with serum HDL-C level remains controversial. The polymorphisms of ApoA1+84 TC, but not MspI, are associated with serum HDL-C. The

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