• Although no GWAS results have been

  2019-05-22

  

  Although no GWAS results have been reported so far from Asian populations, the candidate gene approach identified SNPs in 4q25 and 1q21 as being associated with AF in Asian populations [19,20]. Conflicting data are reported in terms of 16q22; it is associated with AF in Chinese Han [37], but not in

• In an effort to determine whether the primary tumour might

  2019-05-22

  

  In an effort to determine whether the primary tumour might be responsible for “fertilising” the bone “soil” ready for the cancer “seed”, we recently found that a hypoxic gene signature, and more specifically the secreted enzyme lysyl oxidase (LOX) was closely associated with bone metastasis, specifi

• The cardiac GP are a collection of

  2019-05-22

  

  The cardiac GP are a collection of autonomic nervous systems comprising both afferent and efferent as well as sympathetic and parasympathetic fibers [10,11]. Radiofrequency catheter ablation eliminates the most elementary level of vagal innervation by destroying the visceral efferent limb of the par

• We established Wt and two Mt

  2019-05-21

  

  We established Wt- and two Mt- (p.R308P and p.A350_N351ins8)-GATA2-expressing 32D Go 6976 to analyze the cellular effects of Mt-GATA2 (Fig. 3A). Immunofluorescence analysis revealed that Mt-GATA2 showed similar localization in the nucleus as Wt-GATA2 (Fig. 3B). Both Wt- and mutant-GATA2-expressing

• En la condensaci n del Borges y

  2019-05-21

  

  En la condensación del “Borges y yo” se despliega un texto que tanto puede ser considerado perteneciente al orden de la narrativa como al orden del ensayo, e incluso al de la poesía. En palabras de José Miguel Oviedo, “es un cuento que es también un ensayo que es también un poema”. “No sé quién de l

• Prednisone prephase was initiated and led to immediate

  2019-05-21

  

  Prednisone prephase was initiated and led to immediate improvement of clinical status. However, tumour size did not decrease within the prolonged prephase of 11 days (Fig. 1b). Despite additional cyclophosphamide (2×200mg/m2), the patient showed deteriorating clinical condition and fever reappeared

• In conclusion through a series of

  2019-05-21

  

  In conclusion, through a series of experiments we showed that our antigen LALF32-51-E7 combined with alum adjuvant promotes a Th1 immune response and consequently an anti-tumor response in the TC-1 tumor model. Based on our results, we suggest not to underestimate the capacity of Al(OH)3 as adjuvant

• Long QT syndrome LQTS a rare inheritable arrhythmia first de

  2019-05-21

  

  Long QT syndrome (LQTS), a rare inheritable arrhythmia first described by Romano and Ward et al. in the 1960s, is characterized by the prolongation of the QT interval on surface ECGs and an increased risk of potentially fatal ventricular arrhythmias, especially torsade de pointes . In 1995, after ye

• Given the recognized effects of bisphosphonates in

  2019-05-21

  

  Given the recognized effects of bisphosphonates in metastatic breast cancer [14,15] and that potential anticancer effects have been demonstrated in preclinical [16], translational [17], patients with cancer therapy-induced bone loss [18] and Phos-tag based-studies [19,20] a number of clinical trial

• TAK-242 Well designed operational research is needed

  2019-05-21

  

  Well designed operational research is needed to refine this starting point. Research is also needed to find out whether prophylactic valganciclovir treatment in high-risk patients might reduce AIDS mortality as well as blindness, as substantial data suggest. WHO leadership is needed to provide cytom

• In the case reported by

  2019-05-20

  

  In the case reported by Goldstein et al. [2], a Riata ST lead (St. Jude Medical, Sylmar, CA, USA) was used. The authors did not mention whether the lead was a dual-coil system or not. If the lead was a single-coil system, the possibility of an HV short circuit between the RV coil conductor and the d

• br Case report The patient then

  2019-05-20

  

  Case report The patient then achieved disease-free status as noted in a series of routine image studies during regular follow-up at our oncology clinic. In November 2011, she presented due to hematuria for several days. Diagnostic cystoscopy showed a mass lesion on the urinary bladder. Whole body

• Numerous animal studies have demonstrated beyond doubt

  2019-05-20

  

  Numerous animal studies have demonstrated beyond doubt that effective inhibition of osteoclastogenesis or osteoclast function significantly reduces metastatic tumour growth in bone [13–20]. Likewise, clinical trials in patients with non-metastatic or metastatic cancers established that treatment wit

• glucosamine sulfate br There is growing recognition that chi

  2019-05-20

  

  There is growing recognition that children bear a substantial burden of tuberculosis morbidity and mortality. However, in regions where the diagnosis is contingent on smear microscopy, the burden attributable to children, who usually have paucibacillary disease, is grossly underestimated. The down

• br The west African outbreak of Ebola virus

  2019-05-20

  

  The 2014–15 west African outbreak of Ebola virus disease is unprecedented in scale, especially in Sierra Leone, which as of May 15, 2015, had reported 8598 confirmed cases and 3538 confirmed Ebola-related deaths. Sierra Leone\'s response to this emergency has been compromised by a fragile health s

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