• Aurora kinases were initially identified as protein kinases

  2024-05-06

  

  Aurora kinases were initially identified as protein kinases essential for error-free chromosome segregation during mitosis and meiosis. Aurora A appears to control premetaphase events, such as bipolar spindle assembly 3, 4, with Aurora B and C directing metaphase and postmetaphase events, including

• bax pathway Regulators of the DDR have therefore become attr

  2024-05-06

  

  Regulators of the DDR have therefore become attractive targets for cancer therapy primarily through two potential approaches. First, to be used as chemo- or radiosensitisers to increase the effectiveness of standard genotoxic treatments and to help prevent or overcome the development of resistance.

• br Application of bamboo in the food

  2024-05-06

  

  Application of bamboo in the food and pharmaceutical industry For decades, the application of antioxidants in the food and pharmaceutical industry has been widespread. In the past, antioxidants were previously used to control oxidation and retard spoilage but today, many are used because of putat

• Aggregated A species have been studied by an array

  2024-05-06

  

  Aggregated Aβ species have been studied by an array of biophysical techniques, including atomic force microscopy (AFM) [55], transmission electron microscopy (TEM) [56], [57], X-ray diffraction [58], Fourier transform infrared (FTIR) [59], [60], circular dichroism (CD) [61], and nuclear magnetic res

• br Applications of ATN in

  2024-05-06

  

  Applications of ATN in clinical trials In pivotal trials, the use of biomarkers will also have to be considered in the context of regulatory risk and scrutiny. Although an important intended application of the framework is in research studies, its use will undoubtedly impact clinical development

• br Experimental br Acknowledgment br Introduction The NADPH

  2024-05-06

  

  Experimental Acknowledgment Introduction The NADPH-dependent reduction of d-glucose catalyzed by aldose reductase (E.C.1.1.1.21) (AR) is considered as one of the phenomena leading to the onset of long term diabetic complications [as review see: [1], [2]. In fact, the reduction of the sugar,

• Since the first studies of betaine aldehyde oxidation in rat

  2024-05-06

  

  Since the first studies of betaine aldehyde oxidation in rats [13], the participation of betaine in the detoxification of homocysteine has well described, considering the activity of other Octreotide acetate as betaine homocysteine methyltransferase and methionine synthase. But, there is a lack of

• br Hypothesis The hypothesis is that AhR

  2024-05-06

  

  Hypothesis The hypothesis is that AhR in skin diseases could be an objective of study for future dermatological therapies. Both stimulation and inhibition of the receptor might have significant influences on neoplastic or inflammatory skin diseases. However, at present the functions of AhR are un

• Edoxaban receptor Given the profound expression of HT

  2024-05-06

  

  Given the profound Edoxaban receptor of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are revers

• The results also showed that the A receptor http www

  2024-05-06

  

  The results also showed that the A3 receptor agonist increased the phosphorylated levels of Akt, leading to activation of the PI3K/Akt pathway. A3 GS-9620 sale stimulation has protective effects against RGC death following ischemia-reperfusion, glutamate toxicity, and optic nerve transection models

• Adenosine is an endogenous nucleoside that

  2024-05-06

  

  Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the Purvalanol B synthesis and in the periphery. The adenosine receptors (ARs) are four different subtypes of G protein-co

• With the treatment options available today including a combi

  2024-05-03

  

  With the treatment options available today including a combination of symptomatic treatments and general immunosuppression, many MG patients can lead productive lives [1], [4], [20]. The frequency of death has decreased due to improved management and detection of milder cases. At present, the overal

• br Results br Discussion Although they do not have protein

  2024-05-03

  

  Results Discussion Although they do not have protein-coding capacity, lncRNAs make up a large part of the transcripts of the genome, and they play fundamental roles in carcinogenesis and osteosarcoma progression through regulation of tumor proliferation and metastasis. These lncRNAs include MA

• cell adhesion molecules Recent findings imply that proper Na

  2024-05-03

  

  Recent findings imply, that proper Na+/K+-ATPase function is crucial for unimpaired development of the vertebrate heart. Targeted knockout of Na+/K+-ATPase α1 in mice led to early embryonic lethality whereas heterozygous knockout mice displayed severe hypocontractile hearts [52]. Pharmacological inh

• br Results A total of respondents completed the

  2024-05-03

  

  Results A total of 126 respondents completed the survey (68.5% response rate), with at least 65% response rate from each of the four represented sectors (denominators represent the total constituent body of the organization or the total attendees of the meeting): PUC 24 out of 37 (65%), SPUNZA 33

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