• Because ASK signaling in microglia and astrocytes is

  2025-02-24

  

  Because ASK1 signaling in microglia and astrocytes is important during EAE, we hypothesized that a combination therapy that targets T cells along with microglia and astrocytes would further ameliorate the severity of EAE. We tested this hypothesis by applying valproic 486 2 (VPA)—a short-chain fatty

• Epothilone D Dopaminergic neurons are vulnerable to oxidativ

  2025-02-24

  

  Dopaminergic neurons are vulnerable to oxidative products and inflammatory responses; these processes may play important roles in the etiology of PD. Because glial Epothilone D are the main generators of inflammatory responses in the CNS, the possibility that PD results from glial cell dysfunction m

• AGN 194310 br Introduction Active oxygen radicals in the

  2025-02-24

  

  Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant

• Plant pathogenic fungi have caused a lot of economic

  2025-02-24

  

  Plant pathogenic fungi have caused a lot of economic losses to agricultural production worldwide every year. It is necessary to develop an bio-sourced antifungal agent for agricultural use. Many researches have shown that the antifungal activity of quaternized chitosan derivatives is mainly affected

• 5-Iodotubercidin It has been proposed that angiotensin II An

  2025-02-24

  

  It has been proposed that angiotensin II (Ang II) may upregulate COX-2 expression and the subsequent vasoconstrictor prostanoids production through the activation of AT-1 receptors in vascular smooth muscle cells (Hu et al., 2002). Additionally, this peptide is also able to stimulate the generation

• In another study Yerra and Kumar

  2025-02-24

  

  In another study, Yerra and Kumar (2016) used streptozotocin to induce diabetic neuropathy in rats. Mechanical/thermal hyperalgesia, motor/sensory nerve conduction velocities (MNCV and SNCV) and sciatic nerve blood flow (NBF) were evaluated. In vitro studies of Neuro2a (N2A) cell culture were perfor

• Circular dichroism CD provides useful

  2025-02-24

  

  Circular dichroism (CD) provides useful information about protein structure, the extent and rate of structural changes and ligand binding. CD is a form of light AICAR spectroscopy that measures differences in the absorbance of right- and left-circularly polarized light (rather than the commonly use

• A disfun o cognitiva p s

  2025-02-24

  

  A disfunção cognitiva pós‐operatória é uma síndrome perioperatória bem reconhecida, consequência da anestesia e cirurgia cuja causa exata permanece por esclarecer. De que forma DL-Dithiothreitol disfunção cognitiva pós‐operatória e a doença de Alzheimer podem estar ligadas permanece uma questão em e

• Heat shock protein Hsp is a molecular chaperone that

  2025-02-24

  

  Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a central role in regulating the maturation, activation and stability of numerous “client proteins” that drive the development and progression of many cancers. Therefore, inhibition of Hsp90 would result in degradation of the client p

• ALK fusion positive NSCLC is clinically

  2025-02-24

  

  ALK fusion-positive NSCLC is clinically actionable because it can be targeted by several FDA-approved drugs, including the first generation TKI crizotinib, which is a dual inhibitor to MET and ALK [15], and the second generation inhibitors, alectinib and ceritinib, both of which are highly-selective

• br Conflicts of interest br Newly Identified

  2025-02-24

  

  Conflicts of interest Newly Identified Mechanisms of APN Resistance Hold Therapeutic Potential APN, APN Receptors, and APN Cardiovascular Protection APN Resistance in Cardiovascular Disease The Molecular Mechanisms of APN Resistance Concluding Remarks and Future Directions Finally,

• Whereas more research is needed to

  2025-02-21

  

  Whereas more research is needed to identify the precise mechanism by which FIN exerts its antidyskinetic effect, the nimodipine that it can negatively modulate dopaminergic transmission is also supported by our previous findings. Indeed, we have previously shown that FIN completely reversed the beh

• Later the same group designed

  2025-02-21

  

  Later, the same group designed and prepared several Δ16-steroidal C17 benzoazoles and pyrazines and evaluated their CYP17 and 5α-reductase inhibitory activities, binding to and transactivation of the AR, as well as their antiproliferative effects against two human PC cell lines (LNCaP and LAPC4) [18

• As mentioned above variation of the A ring was undertaken

  2025-02-21

  

  As mentioned above, variation of the A-ring was undertaken in order to improve microsomal stability and kinase selectivity relative to Cholesterol reduction (). 1-Imidazole-2-carboxamides with substitution at the 4-position (–) were mostly tolerated with 4-cyano-imidazole-2-carboxamide () having co

• Thirty six of the analogs synthesized showed

  2025-02-21

  

  Thirty-six of the analogs synthesized showed ATX inhibition greater than 50% at 10μM with FS-3, twelve of which had improved potency over the lead (Fig. 5). Of these, 22 was sub-micromolar (IC50 670nM). The 3,5-dichlorophenoxy ring of 22 is reminiscent of the 3,5-dichlorophenylthiourea ring in Hoegl

16058 records 12/1071 page Previous Next First page 上5页 1112131415 下5页 Last page