• Tacalcitol Monohydrate: Advanced Mechanistic Insights for On

  2026-04-28

  Explore the unique, evidence-based mechanisms of Tacalcitol monohydrate, a synthetic analog of vitamin D3. This article delivers new perspectives on its VDR- and CaSR-mediated actions, bridging cancer and skin research with detailed, actionable protocol guidance.

• Axitinib (AG 013736): Optimizing VEGFR Inhibition in Cancer

  2026-04-27

  Axitinib (AG 013736) empowers advanced angiogenesis and tumor growth inhibition workflows with exceptional potency and selectivity. This guide details practical protocols, troubleshooting strategies, and innovative applications in cancer biology, translating bench research into reproducible results.

• Antipyrine (SKU B1886) for Reproducible CNS Assays

  2026-04-27

  This article addresses real-world laboratory challenges in CNS-focused cell viability, pharmacokinetic, and blood-brain barrier assays—demonstrating how Antipyrine (SKU B1886) delivers reliable, high-purity performance. By integrating scenario-driven Q&A and quantitative references, we show how researchers can optimize workflows and data integrity using this validated compound.

• Early Life Adversity Impairs Defensive Behavior via Oxytocin

  2026-04-26

  This study establishes that early life adversity (ELA), specifically social deprivation during a critical postnatal window, disrupts innate visual threat responses in mice through deficits in oxytocin signaling within the superior colliculus. These findings elucidate a novel mechanistic link between early social environment and neurobiological circuits governing fear, providing a foundation for future therapeutic strategies.

• Panoramic Opto-Electrical Mapping Advances Mouse Heart Studi

  2026-04-25

  The referenced study introduces the POEMS system, enabling simultaneous panoramic optical and electrical mapping and stimulation of mouse hearts. This technical advance supports more precise investigation of cardiac electrophysiology and optogenetic manipulation, with implications for research into cardiac conduction and arrhythmia.

• STING Agonist-1: Advancing B Cell-Driven Immunotherapy Model

  2026-04-24

  This thought-leadership article explores the mechanistic foundations and translational potential of STING agonist-1, a precision small molecule STING pathway activator, for dissecting B cell-driven antitumor immunity. Integrating new evidence on the STING–CD40–TRAF2–IRF4 axis, it offers strategic guidance for translational researchers, contrasts current reagent options, and positions STING agonist-1 from APExBIO as an essential tool for next-generation immunology and cancer immunotherapy research.

• Brassinolide: Applied Workflows for Plant and Cancer Researc

  2026-04-24

  Brassinolide (24-Epibrassinolide) bridges advanced plant growth modulation with translational cancer and diabetes research, enabling reproducible, cross-domain experimentation. This article delivers evidence-backed protocols, comparative bioassay insights, and troubleshooting strategies to maximize Brassinolide’s impact in both plant and biomedical laboratories.

• RG7388 MDM2 Antagonist: Enhanced p53 Activation in Cancer Mo

  2026-04-23

  RG7388, a next-generation MDM2 antagonist, enables highly selective p53 pathway activation and robust cancer cell apoptosis in wild-type p53 models. This guide outlines experimental workflows, protocol optimizations, and troubleshooting strategies to maximize translational impact for preclinical and translational oncology studies.

• Caffeine (1,3,7-trimethylpurine-2,6-dione): Lab Use Paramete

  2026-04-23

  Caffeine (SKU N2379) is a purine alkaloid used for targeted research in cancer biology, metabolic regulation, and neurobiology. It is not suitable for protocols requiring ethanol solubility or long-term solution storage and should be handled according to defined product specifications for reliable results.

• High-Throughput Surrogate BBB Model: Predictive Power & Vali

  2026-04-22

  This study introduces a high-throughput in vitro blood-brain barrier (BBB) model using LLC-PK1-MOCK/MDR1 cells, integrating lysosomal trapping correction to enhance predictive accuracy for CNS drug permeability. The model demonstrates robust correlation with in vivo brain distribution, offering a scalable tool for early CNS drug candidate screening.

• Cell Surface GlycoRNA–RBP Nanodomains Enable Peptide Entry

  2026-04-22

  This study uncovers the presence and functional organization of RNA-binding proteins (RBPs) and glycoRNAs on the cell surface, forming nanoclusters that act as entry sites for cell-penetrating peptides. The findings reshape our understanding of cell surface architecture and offer methodological insights for mapping dynamic protein–RNA interactions at the membrane interface.

• Caffeine (1,3,7-trimethylpurine-2,6-dione): Lab Use Guide

  2026-04-21

  Caffeine is a purine alkaloid used in cancer biology, metabolic, and neurobiology research for its role as an adenosine receptor antagonist and metabolic regulator. This article details how to handle, solubilize, and apply Caffeine (SKU N2379) in laboratory workflows, and highlights key limitations for researchers. It should not be used where ethanol solubility or long-term solution stability is required.

• Angiotensin III (human, mouse): Reliable RAAS Peptide for Re

  2026-04-21

  This article addresses key laboratory challenges in cell viability, proliferation, and cytotoxicity assays using Angiotensin III (human, mouse) (SKU A1043). By exploring real-world scenarios, it demonstrates how validated workflows and high-purity reagents from APExBIO improve experimental reproducibility and data quality. Practical protocol guidance and literature-backed insights support confident assay design and interpretation.

• BMP4-GPX4 Axis Mitigates Ferroptosis in Glaucoma Models

  2026-04-20

  This study demonstrates that activating the BMP4-GPX4 pathway protects retinal ganglion cells from ferroptosis and enhances retinal stem cell differentiation in a mouse model of glaucoma induced by N-Methyl-D-aspartic acid (NMDA). The findings suggest a potential therapeutic approach for improving stem cell transplantation outcomes in neurodegenerative retinal disease.

• Reliable Cell Proliferation: EdU Flow Cytometry Assay Kits (

  2026-04-20

  This article examines real-world laboratory scenarios where EdU Flow Cytometry Assay Kits (Cy5) (SKU K1078) provide robust, quantitative cell proliferation analysis. Integrating peer-reviewed findings and workflow best practices, the discussion demonstrates how K1078 advances reproducibility, sensitivity, and safety for S-phase DNA synthesis measurement in biomedical research.

8589 records 14/573 page Previous Next First page 上5页 1112131415 下5页 Last page