• These results must also be addressed in light of

  2023-02-25

  

  These results must also be addressed in light of porcine AMPKγ3R200Q (RN−) mutation. Pigs harboring this mutation produce meat with an abnormally low ultimate pH (pHRapalink-1 meat (Copenhafer et al., 2006, Lundström et al., 1998, Milan et al., 2000). This extremely low pH is very close to the isoe

• From an historical perspective ligands for GPCRs adrenaline

  2023-02-25

  

  From an historical perspective, ligands for GPCRs (adrenaline, serotonin, Imiquimod hydrochloride or morphine, to name a few) have been identified before their receptor counterparts, at a time when the concept of receptor itself was controversial [15]. Although many cognate receptors for endogenous

• br Introduction Active oxygen radicals in the human

  2023-02-23

  

  Introduction Active oxygen radicals in the human body have a strong effect of inducing lipid peroxidation, which in turn induces oxidative imbalance and causes various diseases. Natural polysaccharides are substances with certain antioxidant activity. They are used as antioxidants and have advant

• On the contrary Birrel and colleagues observed divergent pro

  2023-02-22

  

  On the contrary, Birrel and colleagues observed divergent proliferative responses to androgens in different BC cell lines: DHT and mibolerone were found to inhibit the T47-D and ZR-75-1 Meropenem trihydrate growth, while the proliferation of MCF-7 cells was increased by both the androgens [53]. It

• About this report Alzheimer s Disease Facts and Figures is

  2023-02-20

  

  About this report 2018 Alzheimer's Disease Facts and Figures is a statistical resource for U.S. data related to Alzheimer's disease, the most common cause of dementia. Background and context for interpreting the data are contained in the Overview. Additional sections address prevalence, mortality a

• There are two ways to transport FFAs into cells First

  2023-02-20

  

  There are two ways to transport FFAs into cells. First by passive diffusion. Second as the putative long-chain fatty 366 2 sale transporters are proposed, CD36 the plasma membrane-associated fatty acid-binding protein (FABPpm) and fatty acid transport proteins (FATP) [11], where CD36 is responsible

• The nAChR has been considered an interesting potential

  2023-02-20

  

  The α7 nAChR has been considered an interesting potential target for numerous therapeutic indications over the last two decades, with GTS-21 one of the first candidates proposed for Alzheimer's disease [2], [3], [23]. Unfortunately, although many α7-selective agonists have been developed [21], none

• However there are studies revealing the dark side of

  2023-02-20

  

  However, there are studies revealing the “dark side” of autophagy at later stages in cancers, when oncogenes (mainly K-ras and B-raf) are activated and/or tumour suppressors such as PTEN and p53 are inactivated. These studies are based on the use of GEMM and deletions of essential autophagy genes (A

• The GRAVY value for a

  2023-02-20

  

  The GRAVY value for a protein is calculated as the sum of hydropathy values of all the amino acids, divided by the number of residues in the sequence (Kyte and Doolittle, 1982). According to Kyte and Doolittle (1982) integral membrane proteins typically have higher GRAVY scores than do globular prot

• The Type A series contains

  2023-02-20

  

  The Type-A series contains 6 of the 11 confirmed hits, making it a highly attractive lead template. Seven (7) out of 8 Type-A series of 3-substituted-2-furoic acids are highly active (84–100% inhibition) at the high concentration of 100μM. We could deduce some interesting, albeit preliminary structu

• The ambiguity surrounding the role played by the LOXs in

  2023-02-20

  

  The ambiguity surrounding the role played by the 15-LOXs in malignant biological processes stems also from the limitations of current animal models, and especially the usage of its 12/15-LOX murine homolog, which can also catalyze the production of 12-HETE. Indeed, the proinflammatory effect of 12-H

• Suspecting that ACL might regulate the expression or

  2023-02-20

  

  Suspecting that ACL might regulate the expression or activity of myogenic transcription factors, Das knocked down MyoD and found that such intervention abolished the effect of ACL on fast MyHC expression and that, conversely, MyoD overexpression partially rescued reduced fast MyHC expression caused

• Cerebral ischemia occurs following the occlusion

  2023-02-20

  

  Cerebral ischemia occurs following the occlusion of a cerebral artery by a thrombus and causes cell swelling due to cytotoxic edema and BBB disruption with vasogenic edema (Loreto and Reggio, 2010, Nakaji et al., 2006, Shibata et al., 2004). Vasogenic edema is directly linked to alteration of the BB

• br In vivo visualization of aromatase with positron emission

  2023-02-20

  

  In vivo visualization of aromatase with positron emission tomography (PET) Positron emission tomography (PET) utilizes the high ppar antagonist photons formed during the annihilation of positrons to detect the changes in the amount and localization of injected radiopharmaceuticals in the living b

• APJ receptor expression is altered

  2023-02-20

  

  APJ receptor expression is altered in various cardiovascular diseases, and both increases as well as decreases in APJ receptor expression have been reported. A decrease in mRNA and protein levels of APJ receptors was observed in patients with ischemic heart disease or idiopathic dilated cardiomyopat

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