• br For some time it was known that

  2022-07-18

  

  For some time, it was known that membrane-bound guanylate cyclases (GCs) of photoreceptor labetalol hydrochloride in the retina respond to changes in the [Ca]. Lolley and Racz observed that synthesis of cyclic GMP (cGMP) was stimulated at only low [Ca], concluding that Ca has an inhibitory effec

• In contrast the sGC activator BAY relaxed the CC

  2022-07-18

  

  In contrast, the sGC activator BAY 58-2667 relaxed the CC in a concentration-dependent manner (Figure 4B), a response that was significantly increased in the CC of sGCβ1ki/ki mice compared with WT mice. The finding that BAY 58-2667 also possessed a corporal relaxing effect in WT mice is suggestive b

• GSTs have been originally named ligandins because

  2022-07-18

  

  GSTs have been originally named ‘ligandins’ because of their capacity to bind large ligand molecules (of molecular weight >400 Da) (Oakley et al., 1999). At least three separate WM-8014 have been reported for xenobiotics within the H-site; only one is for CDNB (Ralat and Colman, 2004). Usually, the

• The Fe deficiency treatment significantly

  2022-07-16

  

  The Fe-deficiency treatment significantly increased the shoot/root Fe ratios in both WT and transgenic lines (Fig. 5C), which implied that the Fe distribution from root to shoot may be an adaptive mechanism or stress response in tomato plants. Thus, the overexpression of GSNOR had a positive effect

• br Acknowledgments br Introduction Obesity and type diabetes

  2022-07-16

  

  Acknowledgments Introduction Obesity and type 2 diabetes (T2D) are two major chronic non-communicable diseases that are increasing worldwide at an alarming rate; the majority of people with T2D are overweight or obese, and T2D associated with obesity is expected to have doubled by 2030 (Chen e

• In our studies the EC values for

  2022-07-16

  

  In our studies, the EC50 values for long-chain unsaturated fatty acids added to the short form of human GPR120 receptor (BC101175), were higher than the EC50 values previously reported (Hirasawa et al., 2005) for the long form of GPR120 (NM_181745), which was co-expressed with Gα16 protein.(Table 2)

• br Methods and materials br Results and

  2022-07-16

  

  Methods and materials Results and discussion Conclusions This is the first study that attempted to isolate, purify and identify the characteristics of brompheniramine maleate from ginseng. In vitro studies have demonstrated that PGL-1 efficiently suppressed SH-SY5Y cell apoptosis induced b

• Young et al described the

  2022-07-16

  

  Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c

• Since the late s synthetic GC e g prednisone prednisolone

  2022-07-16

  

  Since the late 1940s, synthetic GC (e.g. prednisone, prednisolone, dexamethasone) have been used extensively in the treatment of chronic inflammatory conditions such as rheumatoid arthritis and asthma, and for their immunosuppressant action in preventing organ rejection post transplantation. Cortico

• Immunohistochemistry analysis shown ghrelin and GHSR a immun

  2022-07-16

  

  Immunohistochemistry analysis shown ghrelin and GHSR-1a immunostaining was located in the epithelial cells of mdm2 p53 and ducts throughout the lactation, strong immunoreactive cells were detected in L30, L60 and L120 stage. The distribution of ghrelin has been shown in many tissues, including mamma

• It has also been demonstrated that PS is ubiquitinated by

  2022-07-16

  

  It has also been demonstrated that PS1 is ubiquitinated by Caenorhabditis elegans SEL-10 [52], Fbw7 the mammalian homologue of SEL-10 [38], and more recently by tumour necrosis factor Necrosulfonamide australia associated factor 6 (TRAF6), which facilitates Lysine-63 (K63)-linked polyubiquitination

• Clinical trials of all GSIs

  2022-07-16

  

  Clinical trials of all GSIs have ended prematurely, raising the question on our understanding of their target, the γ-secretase/presenilin. Development of compounds to target γ-secretase and reduce Aβ production is complicated by the fact that γ-secretase/presenilin has critical biological function,

• br Conflict of interest statement br Acknowledgements br Int

  2022-07-16

  

  Conflict of interest statement Acknowledgements Introduction Galanin is a multi-functional neuropeptide that is widely distributed in the neuroendocrine system and peripheral tissues of various species. This 29-amino-acid peptide (30 in humans) is proteolytically processed from its precurso

• In addition at the spinal level results from

  2022-07-16

  

  In addition, at the spinal level, results from colocalization experiments demonstrate that GABA-C receptors are present in the substantia gelatinosa and that they are presynaptically located. Neurons located in the substantia gelatinosa are differentially activated by afferent noxious and non-noxiou

• br Material and methods br Results and discussion

  2022-07-16

  

  Material and methods Results and discussion Discussion It is well established that the guanosine-rich DNA sequences within telomeric DNA repeats, and in the promoter regions of a number of oncogenes or proto-oncogenes such as c-myc [20,23], VEGF [28,48,49] and Bcl-2 [21,50], can readily ass

16042 records 432/1070 page Previous Next First page 上5页 431432433434435 下5页 Last page