• During the past decades HT had

  2020-02-15

  

  During the past decades HT had been widely prescribed with the expectation of both osteoporosis and cardiovascular disease prevention. The results of the Women\'s Health Initiative (WHI) trial, however, indicated that long-term HT use is associated with a small but significant increase of cardiovasc

• br Acknowledgements br Introduction L Rhamnosidases

  2020-02-15

  

  Acknowledgements Introduction α-L-Rhamnosidases (EC 3.2.1.40) are glycosyl hydrolases (GHs) that cleave terminal α-l-rhamnose from a large number of natural products [1]. The action of α-L-rhamnosidases (α-RHAs) has been reported, among others, on different complex substrates such as heteropol

• br Use of recombinant collagen to study

  2020-02-14

  

  Use of recombinant collagen to study DDR–collagen interactions Synthetic peptides have proven highly valuable in replicating the characteristics of collagen and in defining the sites on collagen essential for binding and studying protein–collagen interactions. There are, however, disadvantages to

• To further verify the effect of

  2020-02-14

  

  To further verify the effect of BBR on ACAT2 protein expression, we have conducted an in vitro permeability assay using Caco-2 monolayer. This assay has long been used to predict the in vivo H-Ser-OH and bioavailability of a compound. It was observed that the amount of cholesterol esters in the med

• Amphiphilic compounds lower interfacial tension and its biol

  2020-02-14

  

  Amphiphilic compounds lower interfacial tension and its biological production often results in a competitive environmental advantage (Darvishi et al., 2011). The reduction of interfacial tension can increase the biologically available surface areas resulting in increased metabolism of insoluble comp

• br Significance Our understanding of the ubiquitin

  2020-02-14

  

  Significance Our understanding of the ubiquitin biology has been rapidly expanding. The role of the ubiquitin system in the pathogenesis of numerous disease states has increased the interest in finding new strategies to pharmacologically interfere with the enzymes responsible of the ubiquitinatio

• Imiquimod It was reported that the expressions of

  2020-02-13

  

  It was reported that the expressions of DPP-4 and SDF-1α increase through HIF-1α [27], [28]. Myocardial ischemia by MI enhanced the DPP-4 and SDF-1α levels in myocardium in the present study. SDF-1α is released from cardiomyocytes and has beneficial effects on cardiomyocytes through SDF-1α/CXCR4 aft

• Cy5 amine (non-sulfonated) We initially identified four puta

  2020-02-13

  

  We initially identified four putative Egr1 Cy5 amine (non-sulfonated) (−39/−36, −105/−102, −107/−104, and −227/−224) on the DBH proximal promoter. The deletion and mutagenesis experiments indicate that the motif at −227/−224 is required for Egr1-elicited reduction in DBH promoter activity. It remain

• br Acknowledgments br Introduction Heterocyclic chemistry ha

  2020-02-13

  

  Acknowledgments Introduction Heterocyclic chemistry has become one of the most important fields of research in pharmaceutical industry due to their many fold applications. Amongst all, heterocyclic Glimepiride containing nitrogen and oxygen have shown most potent biological activities. It fol

• Among the other mediators which have been reported to

  2020-02-13

  

  Among the other mediators which have been reported to play a role in erection are prostaglandins (PGs). Several studies have reported that alprostadil- synthetic PGE1- showed high efficacy in management of erectile dysfunction as it induces corpus cavernosal relaxation. Alprostadil has been first de

• Many studies have shown that curcumin delays

  2020-02-13

  

  Many studies have shown that curcumin delays the progression of atherosclerosis in different atherosclerotic animal models [18], [19], [20], [37] and the risk of atherosclerosis in human studies [15], [38], [39]. Curcumin also has many properties that contribute to combat atherosclerosis, such as an

• Data on optimal hormone formulations routes of administratio

  2020-02-13

  

  Data on optimal hormone formulations, routes of administration, doses and duration of hormone use in young women with POF are lacking (Box 1). Transdermal Topiroxostat administration, which avoids the first-pass hepatic circulation and the increase in inflammatory markers such as C-reactive protein

• br Materials and methods br Results

  2020-02-13

  

  Materials and methods Results Discussion TP has aroused extensive explorations because of its potent anti-inflammatory, immune-suppressive and antitumor activities. Notwithstanding these, TP has yet to enter Phase II clinical trials owing to its severe toxicity (Zhou et al., 2012). TP could

• (R)-(-)-Niguldipine hydrochloride Today many strategies have

  2020-02-12

  

  Today, many strategies have been developed to enhance CXCR-4 receptor (R)-(-)-Niguldipine hydrochloride on the cell surface, either by modifying the cell culture medium or by modifying the CXCR-4 gene in BMSCs to stimulate stem cell recruitment (Jiang et al., 2012, Liu et al., 2014b). For instance,

• Sensory gating describes a filter mechanism

  2020-02-12

  

  ‘Sensory gating’ describes a filter mechanism protecting the central nervous system from sensory overload by inhibiting behaviorally irrelevant input (Boutros et al., 2004, 2008). This permits cystamine to a changing contextual environment (Fruhstorfer et al., 1970; Grunwald et al., 2003). Auditory

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