• However with regard to the involvement of PEP in neoplastic

  2019-10-02

  

  However, with regard to the involvement of PEP in neoplastic processes, few studies and restricted to a very limited number of different tumors have been carried out [4], [18], [19]. Therefore, in order to ascertain the possible role of this enzyme in pathological proliferative tissues, in the prese

• br Results br Discussion Drug resistance

  2019-10-01

  

  Results Discussion Drug resistance poses the greatest hurdle of achieving high efficacy with AADs in cancer patients. AAD-treated cancer patients often encounter intrinsic and evasive drug resistance that diminishes the therapeutic efficacy to only minor survival benefits in most cancer types.

• Tolcapone pathway In summary these findings show that the

  2019-10-01

  

  In summary, these findings show that the knockdown of tra2 in the Drosophila fat body results in an increased triglyceride phenotype, which could be explained in part by altered splicing of the gene coding for the lipid breakdown enzyme, CPT1. These findings are consistent with previous studies anal

• Like professional accounting organizations many accounting e

  2019-10-01

  

  Like professional accounting organizations, many accounting educators have also embraced the potential recruitment value of advanced placement. For example, high school and college educators collaborated to create the Accounting Pilot and Bridge Project (APBP), in order to jump start the profession\

• During recent years two primary types of models

  2019-10-01

  

  During recent years, two primary types of models have been applied for calculating various thermodynamic properties of amino tetrandrine solutions, i.e. excess Gibbs energy (gE) models used numerously to describe the solubility of amino acid solutions, and equations of state (EOS) models appropriat

• br Introduction Al Awqati and his colleagues

  2019-10-01

  

  Introduction Al Awqati and his colleagues using R(+)-methylindazone, R(+)-[(6,7-dichloro-2-cyclopentyl-2,3-dihydro-2-methyl-1-oxo-1H-inden-5-yl)-oxy] acetic 64c (IAA-94) (Landry et al., 1987) isolated the first chloride intracellular ion channel (CLIC) proteins (p64) from bovine kidney cortex mi

• The role of ETB clearing receptors has been studied in

  2019-10-01

  

  The role of ETB clearing receptors has been studied in detail in endothelial cell–specific ETB knock-out mice. In these animals, clearance of an intravenous ACSF of labeled ET-1 was reduced significantly compared with wild-type controls. Importantly, functioning ETB were retained on all other cell

• Because sex steroids and growth hormone play an

  2019-10-01

  

  Because sex steroids and growth hormone play an important role in the development and maintenance of hepatic CYP450 enzyme expression and ER expression, it is possible that exposure to endocrine active agents during gestation and perinatally could alter expression of these proteins. Therefore, these

• Milrinone kinase Among the Ub interactions observed in the H

  2019-10-01

  

  Among the ~Ub interactions observed in the HOIP structure is one that involves a RING2 domain (from the non-cognate HOIP) [47]. A similar binding interaction was defined between HHARI RING2 and the hydrophobic patch on Ub by NMR [54]. HHARI RING2 mutations that ablate the interaction inhibit formati

• Currently much effort has been made to design and synthesize

  2019-10-01

  

  Currently, much effort has been made to design and synthesize ThDP analogs (such as ThTDP, ThTTDP, and triazole-ThDP in Fig. 2)8, 9, 10, 11, 12 as PDHc E1 inhibitors. These ThDP analog inhibitors, such as ThTDP and ThTTDP, can block the ThDP binding site, and exhibit significantly stronger binding a

• Prostaglandins PGs are lipid mediators that

  2019-09-30

  

  Prostaglandins (PGs) are lipid mediators that exhibit a variety of physiological properties by interacting specific G protein-coupled receptors (GPCRs) [10]. PGD2 is synthesized from PGH2 through two distinct PGD synthases; lipocalin-type PGD synthase (L-PGDS) and hematopoietic PGD synthase (H-PGDS)

• Autophagy is a dynamic process that primarily involves autop

  2019-09-30

  

  Autophagy is a dynamic process that primarily involves autophagosome formatting and lysosomal degradation, and these processes are controlled by autophagy-related genes (Atg) (Klionsky et al., 2012). The related protein SQSTM1/p62 (sequestosome 1) importantly serves as a signalling director in sever

• In humans individual differences in prefrontal dopamine are

  2019-09-30

  

  In humans, individual differences in prefrontal dopamine are partially caused by the Val158Met single-nucleotide polymorphism on the catechol-O-methyltransferase gene (COMT). This gene controls activity of the COMT enzyme, which degrades extracellular catecholamines including dopamine. The Val varia

• Not all of the biological activities exhibited by

  2019-09-30

  

  Not all of the biological activities exhibited by progestogens (Table 1) are mediated via binding to SRs. For example, the anti-estrogenic action of progestogens in the Gap19 clinical is due to the progestogen-bound PR suppressing ER gene expression, and consequently the ability of the cell to resp

• The activity of cysteine endopeptidases involved in the germ

  2019-09-30

  

  The activity of cysteine endopeptidases involved in the germination of caryopses is generally regulated at two levels: the hormonal induction of synthesis by gibberellins (Drzymała et al., 2008) and a putative regulation of activity by phytocystatines (Kiyosaki et al., 2007, Martinez et al., 2009),

15300 records 937/1020 page Previous Next First page 上5页 936937938939940 下5页 Last page